In-vitro fertilization is an advanced and powerful technique that has helped many couples having trouble conceiving, to get pregnant and have a baby. Therefore, questions like how to tell when IVF has failed could be on many people’s minds. You should know that not every process comes with a guarantee and IVF itself depends on numerous factors for its success.
What is Implantation Failure?
Implantation failure refers to the inability to achieve pregnancy because the embryo, once fertilized by the union of egg and sperm, fails to adhere to the uterine wall to form the gestational sac. It is difficult to find out if the cause of infertility in a couple is due to implantation failures, as it is not possible to know whether or not fertilization takes place while trying to conceive naturally.
Also, it is more common to speak of implantation failure in an in vitro fertilization (IVF) treatment when, after several embryo transfers, the result is always negative.
What Are the Symptoms of Implantation Failure?
After an embryo transfer, there is no sign or symptom that can tell us for sure if IVF has worked or not. In general, if the embryo has not implanted, about 15 days later the premenstrual symptoms will begin and, finally, menstrual bleeding will arrive to confirm the implantation failure.
To take a different approach however, the IVF implantation failure symptoms can be quite evident by the absence of any changes. Implantation generally causes changes in the tendency to smell, increased sensitivity of breasts, vaginal discharge, and slight abdominal cramping. If these don’t exist even after a couple of weeks, post IVF, it might be indicative of a failure.
Vaginal bleeding may also be a sign of an ectopic pregnancy. This occurs when a fertilized egg implants into one of the fallopian tubes rather than that of the lining of the uterus. Some other symptoms may include pain in the abdomen, pelvis, or even the shoulder.
What Are the Main Causes of Embryo Implantation Failure?
Failure of implantation with IVF can occur due to problems with the quality of the egg or sperm, smoking, suboptimal laboratory culture conditions, and problems with uterine receptivity. Problems with uterine receptivity can occur due to fibroid polyps, septum, hydrosalpinges, chronic endometriosis, and inadequate development of the uterine line (thin endometrium).
Why Does IVF Fail?
After transfer, there may be several reasons why a cycle may fail. While doctors take all necessary measures to prevent a failed cycle, they cannot prevent or fix what happens after the transfer. . The egg and sperm used to create the embryo were not of high quality. . The embryo has a genetic or chromosomal abnormality. . The embryo was not able to hatch and implant. . The uterine lining was not receptive enough for the embryo. . Lifestyle factors such as exercise intensity, diet, or substance use can negatively affect treatment at any stage, including what happens after transfer. . Immunological problems can attack the embryo and cause implantation failure. After a failed IVF transfer, the various reasons listed above can be carefully investigated and the information can lead to a more successful cycle next time.
There are various reasons for failure of implantation. Implantation is one of the natural processes that occur during IVF. After the transfer phase, there is little that doctors and patients can do to prevent implantation failure. All measures taken are either preventative or what is learned from a failed cycle informs the decisions made in the next cycle. . The lining of the uterus is too thin to support an embryo. . The blastocyst had a good morphology but had genetic abnormalities. . The patient has hormonal or anatomical problems that prevent the implantation of the embryo. . The immune system sees the embryo as a foreign object and does not allow it to implant. In some cases, the cause of implantation failure cannot be determined.
How to Prevent Implantation Failure?
There are stories of various home remedies, nutritional supplements, or foods you can take to improve implantation failure that have no scientific data to back them up. Instead, we provide you with steps you can take with your doctor to increase your chances of implantation. . If you haven’t changed your lifestyle to be healthier, start it. This improves the quality of the eggs and sperm and leads to higher-quality embryos. . Ask your doctor to use Pre-implantation Genetic Testing to see which embryos are of higher quality and therefore have a better chance of implantation. . Choose Assisted Hatching to give the embryo the best chance of implantation, especially if you are going through a frozen cycle. . If the problem is with the uterine lining, going for a frozen embryo transfer can be helpful. With frozen embryos, doctors can optimize the uterine lining to make it more receptive. . Ask for tests like ALICE, ERA, and EMMA to find out about the condition of your uterine lining and determine when your uterus is most receptive. . Ask for immunology tests, such as Natural Killer Cell tests to find out if the cause of your infertility is immunological.
What are my Options after Failed IVF?
After you’ve given yourself some time to heal, you might want to think about what you want to do after this cycle. Some of the possible options are as follows: . You can you start another IVF cycle and use adjunct treatments that increase your chances, such as PGT or the ERA test. You should talk to your doctor about what could have caused things to go wrong in the last cycle and what you can do in the next cycle to make it less likely to happen again. Keep in mind that you need to wait 1-2 months between cycles. . If your cycles fail due to egg, sperm, or embryo quality, you may consider using donor gametes or a donor embryo. . If you have recurrent implantation failure and miscarriage, you may want to consider surrogacy. You may consider adoption to become a parent. . You may decide to stop fertility treatments temporarily or permanently and consider a child-free lifestyle.
About Iranian Surgery
Iranian surgery is an online medical tourism platform where you can find the best ivf center in iran. The IVF cost in Iran can vary according to each individual’s case and will be determined by an in-person assessment with the doctor.
For more information about the cost of IVF in Iran and to schedule an appointment in advance, you can contact Iranian Surgery consultants via WhatsApp number 0098 901 929 0946. This service is completely free.
