ICSI IVF procedure in Iran

ICSI IVF procedure in Iran

What is ICSI?

ICSI procedure step by step

Who is ICSI suitable for?

What Is the Procedure for ICSI-IVF?

What is the success rate of ICSI?

Can ICSI affect a baby’s development?

Is ICSI treatment painful?

What is the difference between ICSI and IVF?

How successful is ICSI?

Intracytoplasmic Sperm Injection (ICSI) is performed as an additional part of an IVF treatment cycle where a single sperm is injected into each egg to assist fertilisation using very fine micro-manipulation equipment. In most cases, ICSI can be used to overcome severe male infertility.


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ICSI procedure step by step

1. Preparing for ICSI

This involves the use of a hormonal drug treatment that stimulates maturation of multiple eggs in the ovaries, in order to create several viable embryos (the following fertilization), also to significantly increase the probability of maintaining the potential for pregnancy and preventing the need for repeated treatments.

2. Egg Retrieval

Hormone preparation for ICSI involves drugs that prevent rupture of mature follicle (ovulation), which allows doctors to perform a minimally invasive oocyte aspiration procedure.

3. Collecting Semen

Depending on the sperm count, if the number of sperm in an ejaculation sample is insufficient, the specialist may have to perform an aspiration (fine needle technique) to extract sperm. If this too, is insufficient, then a testicular sperm extraction (TESE) or biopsy is undertaken.

4. Insemination

Intracytoplasmic sperm injection is performed under microscopic control. A single sperm is injected into the cytoplasm of the retrieved egg. Experts at HMC carefully control the process of fertilization and the embryos are moved to a special incubator.

5. Transfer and Monitoring Embryonic Development

Within the 48 hours that follow ICSI fertilization, there is much cell division of the embryo. Specialists then select the healthiest embryos and transfer them to the uterus. Patients have the option to cryopreserve the viable embryos that were not transferred to the uterus. Implantation of the embryo, a few weeks later if the treatment is successful and there is a positive pregnancy result (after 14 days), specialists continue to perform a routine ultrasound to monitor pregnancy.


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Consultation with iranian doctor



Is ICSI treatment painful?

Needle aspiration is a simple procedure performed under sedation with minimal discomfort; however, there is the potential for pain and swelling afterward. The sperm obtained from the testis is only appropriate for ICSI procedures when testicular sperm is not able to penetrate an egg by itself.

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Who is ICSI suitable for?

Intracytoplasmic sperm injection is recommended for couple’s who have been diagnosed with male fertility issues such as low sperm count, low sperm morphology or motility, anti-sperm antibodies or have previously had a vasectomy or unsuccessful vasectomy reversal.

We can also use this technique for couples who have experienced poor or no fertilisation rates using standard IVF.  Patients are electing to undergo ICSI for reasons other than male factor infertility, including:

  • Previous poor fertilization with IVF
  • Variable sperm counts
  • Unexplained infertility

Many patients choose to undergo the ICSI procedure in order to maximize their success even when the procedure is not clearly indicated.

If you have been told that there are abnormalities with any sperm test results, you should give serious consideration to ICSI. If the male partner has had a vasectomy reversal, we also recommend ICSI regardless of the sperm quality because of the presence of sperm antibodies that may affect fertilization.

The decision to proceed with ICSI is particularly difficult if there is no prior evidence of male factor infertility. Some couples choose ICSI because they want to do everything possible to maximize fertilization. However, it is important to understand that for many couples with normal sperm parameters, maximal fertilization can be achieved with standard insemination during IVF without the use of ICSI.

Read more about: How long does it take to get pregnant with ICSI

What Is the Procedure for ICSI-IVF?

ICSI is done as a part of IVF. Since ICSI is done in the lab, your IVF treatment won't seem much different than an IVF treatment without ICSI.

As with regular IVF, you'll take ovarian stimulating drugs, and your doctor will monitor your progress with blood tests and ultrasounds. Once you've grown enough good-sized follicles, you'll have the egg retrieval, where eggs are removed from your ovaries with a specialized, ultrasound-guided needle.

Your partner will provide his sperm sample that same day (unless you're using a sperm donor or previously frozen sperm.)

Once the eggs are retrieved, an embryologist will place the eggs in a special culture, and using a microscope and tiny needle, a single sperm will be injected into an egg. This will be done for each egg retrieved.

If fertilization takes place, and the embryos are healthy, an embryo or two will be transferred to your uterus, via a catheter placed through the cervix, two to five days after the retrieval.

You can get more detailed information here in this IVF Treatment Step by Step.

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What is the success rate of ICSI?

The most important indicator of ICSI success appears to be the fertilization rate achieved with the ICSI procedure. The fertilization rate in the UCSF IVF laboratory is exceptional currently 80 to 85 percent. That is to say, on average, eight out of every 10 eggs will fertilize normally.

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What is the difference between ICSI and IVF?

ICSI differs from IVF as each egg is individually injected with a single sperm, bypassing the stage where the sperm has to naturally penetrate the egg. ICSI is similar to IVF as eggs and sperm are collected from each partner or donor. On the day of egg collection, an embryologist inseminates the eggs and the following day selects out those that are fertilised. They are kept and monitored in an incubator for up to five days and the best embryos are transferred into your womb to implant.

ICSI Risks

 ICSI can increase IVF success rates but the procedure is not perfect. Here are some more common risks associated with ICSI.

Damage to embryos. Fertilization rates with ICSI range from 50 to 80 percent. However, not all fertilized eggs develop into healthy embryos. Unfortunately, some eggs and embryos do become damaged during the ICSI process.

Becoming pregnant with multiples. Since ICSI takes place as part of the IVF process, there is an increased chance of becoming pregnant with multiples for couples that try ICSI. Couples that use ICSI with IVF have about a 30 to 35 percent chance for twins and a 5 to 10 percent chance for having triplets or more.

Carrying multiples increases your chances of developing the following complications during pregnancy and childbirth:

  • Gestational diabetes
  • High blood pressure
  • Low amniotic fluid levels
  • Bed rest
  • Cesarean section or premature labor

Read more about: what is the difference between ICSI and IVF

Can ICSI affect a baby’s development?

If a woman gets pregnant naturally, there is a 1.5% to 3% chance that the baby will have a major birth defect. The chance of birth defects associated with ICSI is similar to IVF, but slightly higher than in natural conception.

The slightly higher risk of birth defects may actually be due to the infertility and not the treatments used to overcome the infertility.

Certain conditions have been associated with the use of ICSI, such as Beckwith-Wiedemann syndrome, Angelman syndrome, hypospadias, or sex chromosome abnormalities. They are thought to occur in far less than 1% of children conceived using this technique.

Some of the problems that cause infertility may be genetic. For example, male children conceived with the use of ICSI may have the same infertility issues as their fathers.

Read more about: ICSI success rate after embryo transfer


10 common questions about ICSI IVF procedure in Iran

1Are birth defects more common with IVF?
The risk of a child with a birth defect in the general fertile population is roughly 3–5 percent. ... A number of studies have indicated that couples with infertility, whether conceiving on their own or through other non-IVF treatment, have the same increased risk of birth defects as those undergoing IVF
2Is ICSI better than IVF?
Research shows that IVF is just as effective as the ICSI procedure, where sperm is injected directly into an egg, when there is no male infertility factor. ... In assisted reproductive technology (ART) there are two ways eggs can be fertilised: IVF (in-vitro-fertilisation) or ICSI (intracytoplasmic sperm injection)
3How can I prevent miscarriage after IVF?
Get in shape before your IVF. At least three months before your treatment, start a health regime. Don't go mad; but be sensible. Stop smoking – a known cause of miscarriage. Stop drinking alcohol, and definitely avoid non-prescription drugs
4Can you have twins with ICSI?
Fertilization rates with ICSI range from 50 to 80 percent. However, not all fertilized eggs develop into healthy embryos. ... Couples that use ICSI with IVF have about a 30 to 35 percent chance for twins and a 5 to 10 percent chance for having triplets or more.
5Are ICSI babies normal?
The rate of birth defects was 6.2% and 4.1% for ICSI and IVF babies, respectively, compared with 2.4% among naturally conceived babies. ... Researchers say all the birth defects were correctable and the children went on to be as normal and healthy as others
6Is IVF or ICSI more successful?
In the 2016 figures, egg donation, when a woman becomes pregnant with another woman's ovum through IVF or ICSI, had a success rate of 50 per cent, making it the most effective kind of fertility treatment.
7Is IVF free in Norway?
The Norwegian government subsidizes a few treatment cycles of ordinary IVF in public clinics. Most other governments do not
8Is IVF legal in Italy?
As Fusion reported this week, Italy has a history of restrictive IVF laws—in fact, it's still illegal for single people and same-sex couples to seek the procedure. ... Last year, Italy loosened its restrictions on sperm and egg donation, so it will be interesting to note the impact over the next few years
9Can you pick gender with IVF?
Gender Selection is a procedure that allows patients to choose the sex of their baby. The selection of the gender of a couple's baby – also referred to as family balancing – is available to New Hope Fertility NYC patients through PGS/NGS testing in conjunction with In Vitro Fertilization (IVF)
10Are IVF babies smarter?
IVF Babies As Intelligent As Peers, Study Suggests Children born from in vitro fertilization score higher on reading and verbal tests than other kids, according to a new study. The findings cast doubt on prior research suggesting IVF babies have lower cognitive abilities


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