Pgd in Iran

Preimplantation Genetic Diagnosis (PGD)

What is Preimplantation Genetic Diagnosis (PGD)?

How much does PGD cost in Iran?

How much does Gender selection cost in Iran ?

Pre-implantation genetic diagnosis (PGD) is a genetic testing procedure performed on embryos created with in-vitro fertilization by examining an embryo for a specific genetic mutation known to cause serious disease. It enables people with an inheritable condition in their family to avoid passing it on to their children.

Dr. Zolghadri

Dr. Jaleh Zolghadri is a specialist reproductive medicine and Infertility, IVF and recurrent pregnancy loss since 1992

Professional Work Experience

1- Specialist Reproductive Medicine and Infertility, IVF and recurrent pregnancy loss since 1992

2- Reproductive Surgery (laparoscopic and Hysteroscopic procedures)

3- Full Professor of OB/GYN, Consultant, Shiraz University of Medical Sciences since 1990.4- Working and supervising infertility fellowship residents in ART & Infertility ward (1991 -2020)

5- Head of the Recurrent Abortion clinic, Shiraz University of Medical Sciences (since 1998)

6- performing many infertility techniques like Microinjection ,Zift, Egg and Embryo donation, Surrogate uterus ,Sex selection, and PGD/PGS

7-Infertility Consultant in Avicenna center of Infertility and recurrent miscarriage

8- Preforming many female Cosmetic surgery like Labioplasty, vaginal rejuvination, tightening and whitening by Monaliza Laser and labia filler injection,PRP and other Aesthetic procedures.

Membership in major
professional societies

1- Member of American Society for Reproduction Medicine (ASRM)

2- Member of American Association of Gynecologic Laparoscopists (AAGL)

3- Member of Middle East Fertility Society (MEFS)

4- Member of Iranian Society for Reproduction Medicine (ISRM)

5- Member of Iranian Society of Surgeon

6- member of American Aesthetic Surgery Society

General information about PGD

The following table describes general information about PGD including PGD cost in Iran, recovery time, and to name but a few.

General Information
Cost	$ 1000
Anesthesia	Local
Hospital Stay	No
Back to Work	1 Day
Minimum Stay in Iran	9 Weeks

Read more about : Icsi procedure step by step

Before Preimplantation Genetic Diagnosis (PGD)

Who should consider PGD?

PGD avoids pregnancy termination as it allows selection of an embryo free of the genetic disease at issue before pregnancy is established. PGD is available for almost any inherited condition for which the exact mutation is known. PGD is best suited for:

. Individuals with known single gene disorder, e.g. cystic fibrosis, cystic disease, Tay Sachs disease.

. Individuals with a chromosomal re-arrangement, e.g. chromosomal translocation in which a segment of a chromosome is found at a location other than its normal place.

. Couple with a child known to have a genetic mutation.

. Couples who desire to match stem cells when a family member is in need of a tissue donor.

During Preimplantation Genetic Diagnosis (PGD)

Preimplantation Genetic Diagnosis (PGD) process Step by step

. Step 1: Stimulation of the ovaries

In order to create embryos for genetic testing, the ovaries have to be artificially stimulated using hormones to produce several eggs at the same time.

Because a significant number of a couple’s embryos are likely to be affected by the genetic or chromosomal abnormality, a large number of embryos need to be created for the best chances of success.

. Step 2: Collection of eggs from the ovaries

At the appropriate time, the eggs are removed in during a surgical procedure known as egg retrieval. Once the eggs are removed, they are inspected to determine which are mature and normal appearing.

. Step 3: Insemination/injection of sperm

Fertilisation during PGD will be done either by:

. In Vitro Fertilisation (IVF): Sperm and eggs are placed together in a culture dish to allow fertilisation to occur.

. Intracytoplasmic Sperm Injection (ICSI): A single sperm is injected in the centre of an egg. This technique is used for conditions caused by a single faulty gene.

Step 4: Fertilisation

The morning after injection/insemination of the sperm, the embryologist carefully examines each egg to see if fertilisation has occurred.

Step 5: Embryo biopsy

The eggs that were successfully fertilised are grown in the laboratory for 5-6 days when the embryo forms what is called a blastocyst of about 100-150 cells. At this stage trophectoderm biopsy (the cells which will form the placenta) takes place.

The removal of these cells should not harm the embryo.

Step 6: Embryo Testing

The cells are tested to see if the embryo from which they were removed contains the abnormality that causes the genetic condition.

Step 7: Embryo Transfer

Only those embryos that do not have the specific genetic condition that was tested for will be transplanted into the woman’s uterus. Usually one embryo will be transferred to the uterus at any one time to avoid the possibility of multiple births (more than one baby in a pregnancy).

Any suitable remaining unaffected embryos will be frozen for later use.

Those embryos that are affected by the inherited condition are allowed to perish or couples are asked if they would consider allowing these embryos to be donated for research and training.

Step 8: Pregnancy Test

Twelve days after the embryo transfer, the woman is given a pregnancy test. A positive pregnancy test means that an embryo has implanted.

Read more about : Can i bend down after embryo transfer?

Read more about : Can you have twins with ICSI?

After Preimplantation Genetic Diagnosis (PGD)

Accuracy of Preimplantation Genetic Diagnosis

The accuracy of PGD will vary, and there is the possibility that testing may not be 100% reliable or conclusive. However, testing is 98-99% accurate for most couples. The risks are dependent upon the condition for which PGD is being offered and the couple’s individual test results.

All patients are offered confirmatory prenatal testing (amniocentesis or chorionic villus sampling) if PGD results in a pregnancy.

What is the Chance of Having a Baby with PGD?

It is difficult to assess success rates for PGD because there is currently little data available. As with most fertility treatments, success depends on many factors, including the woman’s age and weight.

Additionally, sometimes no embryos are suitable for transfer to the womb, for reasons including:

. Not enough eggs were produced or fertilised

. Embryos do not develop to the balstocyst stage

. Embryos do not survive the biopsy, although this is a rare event

. All the embryos were affected by the genetic condition.

Therefore, a pregnancy cannot be guaranteed using PGD.

Preimplantation Genetic Diagnosis (PGD) Cost

The cost of Preimplantation Genetic Diagnosis (PGD) in Iran is $ 1000.

10 common about PGD

1What can PGD test for?

PGD can be used for diagnosis of single-gene defects or chromosomal abnormalities. Single-gene defects are classified into two categories: autosomal recessive and autosomal dominant. Autosomal recessive disorders (i.e. Cystic Fibrosis, ß-thalassemia, Tay-Sachs Disease, Sickle Cell Anemia, etc.)

2What is the difference between PGS and PGD?

PGS analyzes biopsied cells from the embryo to screen for potential genetic abnormalities when there are no known potentially inherited disorders. PGD, on the other hand, uses the same process to detect a specific disorder that has a high probability of being passed down from parents to their offspring.

3Is PGD safe?

Preimplantation genetic diagnosis (PGD) has helped many couples conceive healthy children and is generally considered a safe practice. However, a new long-term analysis of PGD in mice suggests that this procedure may increase risks of weight gain and memory decline in adulthood

4Does PGD reduce miscarriage?

PGD was able to reduce the miscarriage rate by about 50%. The couples who are at highest risk for chromosome abnormalities and miscarriages include those in whom the female is older. In fact, the older the female, the higher the rate of abnormalities found and the higher the miscarriage rate

5Is PGD 100 accurate?

The Accuracy of Preimplantation Genetic Diagnosis (PGD) No procedure is 100 percent accurate, including PGD. Potential drawbacks with the PGD procedure include: Errors in the embryo analysis process, which are very rare but do occur. Damage to the embryo during the biopsy

6Can you do PGD without IVF?

But Katz-Jaffe says that there are none. Bustillo, on the other hand, emphasizes that PGD is not possible without doing IVF first, which can be expensive, inconvenient and carries certain risks, such as ovarian hyperstimulation and multiple gestation, including twins, triplets and beyond

7Is PGD necessary for IVF?

Preimplantation genetic diagnosis (PGD) is being used increasingly at the Fertility Institutes to dramatically improve the chance of a successful IVF pregnancy in couples where prior IVF failures have remained unexplained

8How long does PGD testing take?

PGD test results are available within 7-10 days

9Can PGD detect Down syndrome?

About PGD. PGD is a method of screening eggs or embryos during the in vitro fertilization (IVF) process. ... Down syndrome is one of the conditions that PGD can screen for. Additional conditions include Tay Sachs, cystic fibrosis, sickle cell anemia, and muscular dystrophy

10Can you do PGS and PGD?

Overlap between preimplantation genetic screening (PGS) and preimplantation genetic diagnosis (PGD). ... This applies to both PGS and PGD. All patients who undergo PGD will also have PGS for their embryos. Only a small subset of PGS patients also have PGD

4 Comments

Faiza says:

June 16, 2021 at 1:03 am

I need prices for all types of gender selection methods I need a boy for my last baby to be pls help n reply thanks I’m planning to come from Pakistan in 3 weeks pls advice help.

Reply
- Iranian Surgery Adviser says:
  
  June 16, 2021 at 11:48 am
  
  Hello,
  Gender selection is done in Iran and you can have gender selection by paying $ 1500- 2000.
  For more information, please leave us a message on WhatsApp.
  
  Reply
Jamie says:

February 5, 2022 at 1:45 pm

Hello Doctor
hope you are good
I was wondering if you can explain to me the difference between PGD and Pgs?
regards Jamie

Reply
- Iranian Surgery Adviser says:
  
  February 6, 2022 at 9:23 am
  
  Hello Jamie
  the answer is PGS analyzes biopsied cells from the embryo to screen for potential genetic abnormalities when there are no known potentially inherited disorders. PGD, on the other hand, uses the same process to detect a specific disorder that has a high probability of being passed down from parents to their offspring.
  for more. information you can message our agents via what’s app on this number
  +989019290946
  
  Reply