The cumulative pregnancy rates after frozen embryo transfers, 47.3% in one embryo transfer group and 58.6% in two embryo transfer group, were not statistically different at the time of analysis.
One is best – most of the time.
Research continues to show that transferring one embryo per cycle is the safest option. Transferring two increases the chance of a multiple pregnancy and associated complications. (Not by a huge margin, but the risk is still significant.) These include pre-eclampsia, gestational diabetes and premature birth. From a purely medical angle, single embryo transfer is generally the way to go.
What happens when two embryos are transferred?
Single embryo transfers (SET) should be the initial recommendation for patients. When good quality embryos are transferred, the implantation rate is higher and there is no difference in pregnancy rate. Double embryo transfers should be limited to patients with repeated implantation failure or repeated pregnancy loss. Yet, when two embryos are transferred, women can be reassured that the quality of the second embryo does not seem to affect the pregnancy rate or the risk of twin pregnancy.
Should I have two embryos transferred?
In cycles of in vitro fertilization (IVF), it is routine to stimulate the female’s ovaries to produce multiple eggs to use for fertilization. In many cases, we obtain more than one good embryo to consider for transfer to the uterus. The availability of multiple good embryos allows us to grade them and then choose the best for transfer. It also brings up a common dilemma. Should you consider a single or double embryo transfer? The answer requires us to consider several factors.
The urge to transfer two embryos is sometimes based on the subtle fear that the embryos will somehow be wasted. Embryos not transferred can remain frozen, and frozen embryos can remain viable for 20 years or more.
The intended parents often have the freedom to choose whether to transfer one or two embryos. But they should not make this decision lightly or naively. They should make this decision only after carefully considering the risks to infants and mother, their desire for multiple children, their finances and their clinic’s implantation rate. we strongly recommend the transfer of a single embryo in all cases.
How successful is IVF second time around?
Women who miscarry during their first IVF cycle still have a higher chance of a live birth with subsequent treatment, compared with women who do not get pregnant after their first round.
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