A risk factor is anything that affects your chance of getting a disease such as cancer. Different cancers have different risk factors. You can change some risk factors, like smoking or weight ; others, like your age or family history, you can’t.
But having a risk factor, or even many, does not mean that you will get the disease. Many people with risk factors never get bladder cancer, while others with this disease may have few or no known risk factors.
Still, it’s important to know about the risk factors for bladder cancer because there may be things you can do that might lower your risk of getting it. If you're at higher risk because of certain factors, you might be helped by tests that could find it early, when treatment is most likely to be effective.
Genetics. Family history: Individuals with a family member who has or has had bladder cancer are at an increased risk for developing this disease. Sometimes, family members with bladder cancer have been exposed to the same carcinogen. Other times, they may all have certain genetic abnormalities associated with bladder cancer. Specifically, mutations in genes known as GNT and NAT may trigger changes in the body’s breakdown of some toxins, which may in turn cause cancer cells to form in the bladder wall.