Bladder Cancer Risk Factors

Bladder Cancer Risk Factors

Bladder Cancer Risk Factors

A risk factor is anything that affects your chance of getting a disease such as cancer. Different cancers have different risk factors. You can change some risk factors, like smoking or weight ; others, like your age or family history, you can’t.

But having a risk factor, or even many, does not mean that you will get the disease. Many people with risk factors never get bladder cancer, while others with this disease may have few or no known risk factors.

Still, it’s important to know about the risk factors for bladder cancer because there may be things you can do that might lower your risk of getting it. If you're at higher risk because of certain factors, you might be helped by tests that could find it early, when treatment is most likely to be effective.

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The following factors may raise a person’s risk of developing bladder cancer:

  • Tobacco use. The most common risk factor is cigarette smoking, although smoking cigars and pipes can also raise the risk of developing bladder cancer. Smokers are 4 to 7 times more likely to develop bladder cancer than nonsmokers. Learn more about tobacco’s link to cancer and how to quit smoking.
  • The chances of being diagnosed with bladder cancer increases with age. More than 70% of people with bladder cancer are older than 65.
  • Men are 4 times more likely to develop bladder cancer than women, but women are more likely to die from bladder cancer than men.
  • White people are more than twice as likely to be diagnosed with bladder cancer as black people, but black people are twice as likely to die from the disease.
  • Chemicals used in the textile, rubber, leather, dye, paint, and print industries; some naturally occurring chemicals; and chemicals called aromatic amines can increase the risk of bladder cancer.
  • Chronic bladder problems.Problems associated with increased bladder cancer risks include urinary infections, kidney and bladder stones, and other causes of bladder irritation. Schistosomiasis, a parasitic infection, may reach the bladder and is associated with an increased risk of squamous cell bladder cancer. In the United States, schistosomiasis is very rare. In Africa and the Middle East, where this parasite is more common, squamous cell bladder cancer is more common.
  • Cyclophosphamide use.People who have had chemotherapy with cyclophosphamide have a higher risk of developing bladder cancer.
  • Pioglitazone (Actos) use.In 2011, the U.S. Food and Drug Administration (FDA) warned that people who have taken the diabetes drug pioglitazone for more than 1 year may have a higher risk of developing bladder cancer. However, published studies have shown contradictory results.
  • Personal history.People who have already had bladder cancer once are more likely to develop bladder cancer again.
  • People who have some forms of this parasitic disease are more likely to develop squamous cell bladder cancer. Schistosomiasis is found in parts of Africa, South America, Southeast Asia, and the Middle East,
  • Lynch syndrome.People with an inherited condition called Lynch syndrome, previously called hereditary nonpolyposis colorectal cancer or HNPCC, may have an increased risk of developing bladder cancer (upper and lower tract).
  • Arsenic exposure. Arsenic is a naturally occurring substance that can cause health problems if consumed in large amounts. When found in drinking water, it has been associated with an increased risk of bladder cancer. The chance of being exposed to arsenic depends on where you live and whether you get your water from a well or from a system that meets the standards for acceptable arsenic levels.

Genetics. Family history: Individuals with a family member who has or has had bladder cancer are at an increased risk for developing this disease. Sometimes, family members with bladder cancer have been exposed to the same carcinogen. Other times, they may all have certain genetic abnormalities associated with bladder cancer. Specifically, mutations in genes known as GNT and NAT may trigger changes in the body’s breakdown of some toxins, which may in turn cause cancer cells to form in the bladder wall.

10 common questions about bladder cancer risk factors

1Does bladder cancer run in families?
It's unusual for bladder cancer to run in families, but some types may have a hereditary link. Having one or more immediate family members with bladder cancer doesn't mean you'll get this disease. Although genetics may play a role, other factors that affect your risk, such as lifestyle choices, are under your control.
2What kind of chemicals cause bladder cancer?
Certain industrial chemicals have been linked with bladder cancer. Chemicals called aromatic amines, such as benzidine and beta-naphthylamine, which are sometimes used in the dye industry, can cause bladder cancer
3At what age does bladder cancer occur?
Bladder cancer occurs mainly in older people. About 9 out of 10 people with this cancer are over the age of 55. The average age at the time of diagnosis is 73. Overall, the chance men will develop this cancer during their life is about 1 in 27.30 Jan 2019
4What are considered risk factors for developing bladder and kidney cancers?
While the exact cause of bladder cancer is not known, certain risk factors are linked to the disease, including tobacco smoking and exposure to certain chemicals and gases. Also, people with a family history of bladder cancer have a high risk of developing the disease.
5What causes cancer in bladder?
These abnormal cells form a tumor. Causes of bladder cancer include: Smoking and other tobacco use. Exposure to chemicals, especially working in a job that requires exposure to chemicals.
6Is bladder cancer common in females?
Women & Bladder Cancer. Bladder cancer has long been considered a disease of older men. Though it is more prevalent in men, studies have shown that women are more likely to present more advanced tumors and have a worse prognosis than men at almost every stage of the disease.
7Can you smell bladder cancer?
Smelling Cancer: Device Detects Bladder Cancer From Odor of Urine. The smell of urine is not usually associated with having life-saving properties. ... In the US, an estimated 72,570 new bladder cancer cases will be diagnosed in 2013 with 15,210 succumbing to the disease
8How long can you live after being diagnosed with bladder cancer?
For a person with stage 4 bladder cancer, the 5-year relative survival rate is around 5 percent. This means that the person is 5 percent as likely as someone without cancer to live for a minimum of 5 years after diagnosis.
9What is the first sign of bladder cancer?
In most cases, blood in the urine (called hematuria) is the first sign of bladder cancer. There may be enough blood to change the color of the urine to orange, pink, or, less often, dark red.
10Does bladder cancer spread quickly?
They tend to grow and spread slowly. High-grade bladder cancers look less like normal bladder cells. These cancers are more likely to grow and spread. They can be harder to treat.


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