Table of Contents

Indications for PICSI/ICSI

Good candidate for PICSI

Is PICSI better than ICSI?

What is PICSI in IVF?

Which is better IUI or IVF?

How is ICSI different from IVF?


To determine the efficacy of the physiological ICSI technique (PICSI) vs. conventional ICSI in the prognosis of couples with male factor, with respect to the following outcome measures: live births, clinical pregnancy, implantation, embryo quality, fertilization and miscarriage rates. Intracytoplasmic sperm injection (ICSI) is a laboratory procedure developed to help infertile couples undergoing in‐ vitro fertilization (IVF) due to severe male factor infertility.  ICSI involves the insertion of a single sperm directly into the cytoplasm of a mature egg (oocyte) using a microinjection pipette (glass needle).  ICSI has been available for more than fifteen years and achieves a high overall fertilization rate.

There is now an alternative to the standard ICSI procedure called the PICSI procedure.  This alternative to the standard ICSI was developed to help in the selection of sperm by the laboratory staff.  The PICSI procedure does this by using a tissue media that is commonly used in the in‐vitro fertilization lab today and it is also a major component that surrounds the cells of the egg.

Read more about : Type of Infertility Treatment in Iran

Read more about : Egg donation in iran

Read more about: iui vs ivf vs icsi

Indications for PICSI/ICSI

  • Very low numbers of motile sperm with normal appearance.
  • Problems with sperm binding to and penetrating the egg.
  • Prior or repeated fertilization failure with standard IVF culture and fertilization methods.
  • Frozen sperm collected prior to cancer treatment that may be limited in number and quality.
  • Absence of sperm secondary to blockage or abnormality of the ejaculatory ducts that allow sperm to move from the testes.  In this situation, sperm are obtained from the epididymis by a procedure called microsurgical epididymal sperm aspiration (MESA).
  • Absence of sperm in the ejaculate, but presence of sperm in the testes.  Sperm can be obtained by testicular biopsy.

Read more about: ICSI babies health problems

Good candidate for PICSI

PICSI is highly recommended in these particular cases:

  • Previous failure or low fertilisation even after ICSI.
  • Low embryo quality or their failure to develop (not related to poor egg quality).
  • Repeated miscarriages.

Read more about: ICSI IVF risks

Is PICSI better than ICSI?

The procedure is very simple for the lab and the major difference between what the ordinary ICSI procedure and the PICSI procedure is the actual dish with the hyaluronan. Physiological intracytoplasmic sperm injection (PICSI) did not significantly improve live birth rates compared with standard intracytoplasmic sperm injection (ICSI), and there was no difference between groups in either clinical pregnancy or premature birth, according to findings from a hyaluronic acid-binding sperm.

Read more about: ICSI IVF procedure in Iran

What is PICSI in IVF?

PICSI is a technique used to select sperm to use in ICSI treatment. It involves placing sperm with hyaluronic acid (HA), a natural compound in the body. PICSI identifies sperm that can bind to HA and these sperm are selected for use in treatment.

Read more about: ICSI success rate after embryo transfer

Which is better IUI or IVF?

IUI is often the first treatment suggested to those who want to conceive as it’s less invasive and demanding than IVF. It’s also much more affordable. If you are a woman under 35, most doctors will suggest 3 to 6 cycles of IUI before moving to IVF. With IUI, women under 35 often have a 10 to 15 percent chance of getting pregnant with just one cycle. With an IVF cycle using a woman’s own eggs, the average national success rates range from 45 percent to 50 percent or more for patients under 35 years old.

Read more about: How long does it take to get pregnant with ICSI

How is ICSI different from IVF?

Research shows that IVF is just as effective as the ICSI procedure, where sperm is injected directly into an egg, when there is no male infertility factor. The key difference between IVF and ICSI is how the sperm fertilises the egg. In IVF, the egg and sperm (of which there are multiple) are left in a petri dish to fertilise on their own. In ICSI, one sperm is directly injected into the egg.

Read more about: ICSI IVF twins

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8 Responses

  1. Pingback: nadia
    1. Generally, one cycle of IVF takes about two months. Women younger than age 35 will get pregnant and have a baby with their first IVF egg retrieval and subsequent embryo transfer(s) about half the time. So age is an important factor but not the only one. You may need to have egg/sperm donation or even surrogacy, and time of your stay for each process is different. However for most of our cases we recommend 1 month or even less. To receive specific answer based on your medical documents, please contact our consultant via Whatsapp number +98 922 176 2312 . It’s a free service.

  2. Pingback: jordan
    1. As for choosing a method you should have a consult with our agents via what’s app on this number +98922 176 2312
      and as for Picsi explanation and how it’s done :
      It involves placing sperm with hyaluronic acid (HA), a natural compound found in the body. PICSI identifies sperm that can bind to HA and these sperm are selected for use in treatment. PICSI is a non-invasive procedure performed on a semen sample as an additional step in the ICSI process.

  3. Pingback: yuen
    1. Dear Yuen, there would be no incisions for transferring embryos. The embryo is loaded into a catheter(a flexible tube), which is passed through the vagina and cervix and into the uterus where it is deposited.

  4. Good day

    I am Mahlatsana Ledwaba from the Agricultural Research Council in South Africa.

    I would like to know if your company sells the PICSI dishes

    1. Hello Mr. Ledbawa
      Iranian Surgery is a medical tourism company and we do not sell lab dishes.

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