The survival for bone cancer patients depends upon the particular type of cancer and the extent to which it has spread. The overall five-year survival rate for all bone cancers in adults and children is about 70%. Chondrosarcomas in adults have an overall five-year survival rate of about 80%.
The five-year survival rate specifically for localized osteosarcomas is about 60%-80%. If the cancer has spread beyond bone, the survival rate is about 15%-30%. Osteosarcomas tend to have a more favorable prognosis if they are located in an arm or leg, respond well to chemotherapy, and are generally completely removed at surgery. Younger patients and females also tend to have a more favorable prognosis than males or older patients.
Ewing sarcomas have a five-year survival rate of about 70% when they are found in a localized stage. If they have spread outside of the bone, the survival rate drops to 15%-30%. Factors that are associated with a more favorable prognosis for ewing sarcomas include smaller tumor size, age less than 10 years, having the cancer in an arm or leg (instead of in the pelvis or chest wall), and having a good response to chemotherapy drugs.
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Bone cancers are broken down into separate types based on the type of cell where the cancer began. The most common types of bone cancer include:
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Pain is the most common sign of bone cancer, and may become more noticeable as the tumor grows. Bone pain can cause a dull or deep ache in a bone or bone region (e.g., back, pelvis, legs, ribs, arms). Early on, the pain may only occur at night, or when you are active. As the cancer develops, though, the pain may become more persistent. Other conditions, like osteoporosis or arthritis, may also cause bone or joint pain.
Bone pain in patients with cancer is commonly caused by cancer cells that have spread to the bones, called bone metastases. Treatment for bone pain is intended to relieve the pain, treat fractures, reduce the risk of fracture, and prevent or delay additional bone complications. Treatment options include pain medications, bisphosphonate drugs, radiation therapy, and/or surgery.
A common cause of bone pain is metastatic cancer. The spread of cancer from its site of origin to another location in the body is called metastasis. A bone metastases is not a new cancer, but consists of cancer cells from the original cancer, such as breast, prostate, lung, kidney, or thyroid, that have spread to bone.
Cancer cells can spread, or metastasize, through the blood and lymph systems. Bone is one of the most common locations in the body to which cancer metastasizes. Bone metastasis usually occurs by way of the bloodstream. A cancer cell may break away from the original location in the body and travel in the circulatory system until it gets lodged in a small capillary network in bone tissue. Cancer may also spread to bone by erosion from the adjacent cancer, though this occurs less frequently than spread by the bloodstream.
The pain occurs with bone cancer because the cancer disrupts the balance of normal cellular activity in the bones, causing damage to the bone tissue. Normal bone is constantly being remodeled, or broken down and rebuilt. Cancer cells that have spread to the bone disrupt this balance between the activity of osteoclasts (cells that break down bone) and osteoblasts (cells that build bone), resulting in either weakened or excessively built-up bone. This damage can either stretch the periosteum (thick membrane that covers bone) or stimulate nerves within the bone, causing pain.
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Treatment for primary bone cancer usually includes surgery, chemotherapy and radiotherapy, or a combination of these treatments, with the aim of controlling the cancer and maintaining the use of the affected area of the body. Many people who are treated for bone cancer go into remission (when the symptoms of bone cancer decrease or disappear).
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