Gamete intrafallopian transfer (GIFT) is a tool of assisted reproductive technology against infertility.
Treatment of infertility by GIFT or transfer of sex cells into the uterus. the treatment of infertility by the transfer of sex cells into the uterus or gift is similar to the method of IVF or IVF, but in this way, fertilization occurs naturally after the eggs and sperm are transferred directly into one of the tubes. This treatment is not as common as IVF and constitutes a very small percentage of assisted treatment.
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In the gift method, fertilization takes place in the womb rather than the lab. Although there is no medically superior preference for natural fertilization over artificial fertilization, however, if IVF and microinjection fertilization techniques do not work, the physician may suggest gift and other more invasive methods.
The gift procedure requires that the woman have at least one open, healthy uterine tube. Although this is a more invasive procedure, it may be prescribed by your doctor if:
Also, if your spouse produces low sperm counts, a gift is a good option. Of course, if sperm count is too low, microinjection is a better treatment.
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The early stages of the gift method are similar to the IVF method. Here are the steps to do the gift:
Ovarian Drug Stimulation: At this stage, taking a series of medications causes the formation of several mature eggs and prevents premature release. When taking these medicines, you should usually see your doctor every two to three days for blood tests and ultrasound to check for follicle growth.
Puncture or ovulation: When the eggs are ready to be extracted, the doctor removes the mature eggs from the follicle using vaginal ultrasound and examining the follicles by a needle that enters the vagina.
At each stage of ovarian stimulation and ovulation, usually five to eight eggs are extracted. The next steps of this procedure are different to IVF as follows:
Fertilization: After the eggs are extracted, sperm and oocytes are examined by a specialist and combined in a container to prepare for transfer to the mother’s body at the same time.
Transplantation Surgery: After the sperm and egg are combined, the doctor performs laparoscopic surgery with a small incision on the abdomen and inserts the combined eggs and sperm into the tubes of the uterus, which usually transfer three or four eggs to the uterus and Of course, this number depends on the age of the woman and other factors. The method of fertilization and embryo development is performed in the uterine tubes. Some women have mild pain after laparoscopic surgery.
Embryo implantation: If the sperm succeeds in fertilizing one of the eggs in the uterus, the egg that has become embryonic moves to the uterus and implants in the uterine wall. After implantation, embryonic development begins and after a while becomes embryonic. If more than one egg is transferred, the chance of pregnancy increases, but the likelihood of two or more pregnancies increases.
Pregnancy Test: Usually two weeks after laparoscopy, you can be sure of pregnancy by using a pregnancy test and blood test.
Read more about: ZIFT advantages and disadvantages
Although the gift method, like other fertility aids, increases the chance of fertility, it also has its drawbacks and drawbacks. The following are some of the disadvantages and disadvantages of this method:
Expensive and time consuming: The gift method requires expensive laboratory procedures, medications, and surgery. It also takes a long time to monitor how your body responds to medications, and you should see your doctor many times for blood tests and ultrasound.
Need for Surgery: Unlike the IVF method, in the gift method, the transfer of eggs and sperm into the cervix requires an invasive surgery.
Pregnancy: Because there is usually more than one egg in the uterus, two or more pregnancies are more likely. Being pregnant has a high risk pregnancy and increases the risk of some pregnancy complications.
Possible Treatment Unfinished: Treatment may be stopped mid-way if symptoms of ovarian hyperstimulation syndrome (ohss) occur or insufficient follicle production.
Other problems: In this method, like IVF, because of the fertility drugs that cause multiple follicles to mature simultaneously, the risk of ectopic pregnancy and ovarian hyperstimulation syndrome are higher.
Read more about: gamete intrafallopian transfer
The woman must have healthy tubes for ZIFT to work. The main difference between ZIFT and GIFT is that ZIFT transfers a fertilized egg directly into the fallopian tubes while GIFT utilizes a mixture of sperm and eggs. GIFT and ZIFT are modified versions of in vitro fertilization (IVF). In ZIFT(Zygote Intrafallopian Transfer), the fertilized eggs, called zygotes, are placed in the fallopian tubes within 24 hours but, in GIFT(Gamete Intrafallopian Transfer), the sperm and eggs are just combined together before being inserted and, its fortunate, if one of the eggs will get fertilized inside the fallopian tubes.
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The success rate for ZIFT varies dramatically, depending on a couple’s fertility problem and age. Younger women usually have healthier eggs and higher success rates. ZIFT has a success rate of 64.8% in all cases.
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GIFT is not nearly as popular as IVF today; nonetheless there is still a 50% pregnancy rate per retrieval cycle for GIFT. In older women the pregnancy rate is lower. If an older woman is fortunate enough to yield many eggs, her pregnancy rate can be made equivalent to that of a younger patient by putting in more eggs.