If you’ve been trying to get pregnant for some time, you’re probably no stranger to negative pregnancy tests. You may think you’d get used to them after a while, and some people do, but many find each successive test harder to take. Especially when a pregnancy test is negative after fertility treatment, the disappointment can be even greater. And some may wonder how would their period be like after a negative test. Read on to find your answer.
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Are There Any Symptoms or Signs After the Embryo Transfer That Indicate That IVF Will Be Negative Pregnancy Test?
The only reliable diagnostic test to establish the success or failure of assisted reproduction treatment is the pregnancy test. It can be done either in urine or through a blood test to determine the level of β-hCG hormone (“beta”).
The presence of certain symptoms similar to those that appear at the beginning of pregnancy, around performance of this test, are not indicative of the result. Many of them, such as the feeling of abdominal discomfort, nausea, tiredness or sleepiness are related to the effect of the drugs used in the treatment and may appear even if there is no pregnancy.
On the other hand, the absence of symptoms does not rule out a positive result, since gestation at its beginning is often asymptomatic.
If I Have Vaginal Bleeding, Is It Indicative of a Negative Result? Should I Go for the β-hCG Test?
Vaginal bleeding is a symptom that does not necessarily imply treatment failure. In fact, it may even indicate that implantation has occurred. This is called embryo implantation bleeding.
Therefore, even if the vaginal bleeding occurs in the days around the β-hCG test, it should be performed on the scheduled day informing the specialist of this circumstance.
Due to the frequency with which this symptom appears in cases of positive pregnancy test, we should NEVER abandon the prescribed treatment until the result of the ?-HCG analysis is known.
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What Will the Period Be Like After a Negative Pregnancy Test?
The time when menstruation appears depends mainly on the treatment used. For example:
. In patients who have undergone an embryo transfer in a natural cycle, the period usually starts on the usual and expected day.
. When we administer hormonal medication, it will start two or three days after the treatment has been discontinued. If it does not appear after two or three days, it is recommendable to consult the doctor.
It may be that the first period is different in duration and intensity than usual.
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Since there are many causes of infertility and often several of them are combined, it is very risky to establish a common prognosis for all the cases. It, therefore, implies a personalized evaluation of each case.
It is important to differentiate between the factors to be studied before treatment and the factors that would have a prognostic value when another IVF attempt is carried out after a failure.
Most relevant pre-treatment factors:
. Maternal age. As we explained in this post, the effect of advanced age causes a decline in the number and quality of oocytes.
. If the starting point of the treatment is an altered massculine factor.
. Body mass index (BMI). In women, the ideal BMI is between 19 and 30. Its deviations, especially BMI >30, can lead to a low rate of fertilization and pregnancy. In this case, the patients tend to have ovulatory problems and present a higher risk of miscarriage. In men, obesity adversely affects their reproductive system and it has been observed to tend to increase oestrogen level and reduce testosterone level.
. Cause of infertility. Whether it is single or multiple.
. Antral follicle count (AFC). It is directly related to maternal age and anti-mullerian hormone (AMH) values. With increasing age, we observe a decrease in the follicle count and AMH values.
. Toxic factors. Habits of use of harmful substances, such as tobacco and alcohol, as well as environmental factors, impair treatment outcome.
. If the cause of the sterility is of unknown
. Anatomical abnormalities that may difficult the pregnancy.
Suffering from a tubal factor.
. Ovarian factor. Depending on the ovarian response in a previous cycle, we can modify and/or customize a new attempt based on certain hormone levels. Also, progesterone levels can help us know if endometrial receptivity is optimal.
. Endometrial factor. Abnormalities in the intrauterine cavity, poorly proliferated endometrium, endometritis, immunological factors and blood coagulation abnormalities are the causes of repeated implantation failure (learn more)
. Semen quality. Although with a low number of spermatozoa we can carry out an ICSI, there are certain parameters that could influence the rate of fertilization and that must be considered in a new attempt.
. Embryonic quality. Embryos that reach the blastocyst stage are classified according to their degree of expansion and the quality of their cells. Consequently, a good quality embryo will have a higher pregnancy prediction rate (learn more)
. Laboratory quality control. This category includes air quality, pH, type and characteristics of incubators, use of dim light and type of media in which embryos are cultured. The IVF laboratory must guarantee the best conditions for embryo development
. Experience of embryologists.
When to Try Again After a Negative Pregnancy Test?
In cases where the strategy to be followed is another ovarian stimulation, it is recommended to allow 2 to 3 months to pass. During this time, the medical team and the embryologists will always work together to try to find the cause of the negative β-hCG and the patient will be allowed to make decisions with more calm and let her ovaries rest after the previous stimulation.
Alternatively, and without any doubt, it is not necessary to wait if the plan is to perform a frozen embryo transfer after the negative IVF. In this case the ovaries are “not necessary” and with menstruation the endometrium will have regenerated completely. Therefore, an endometrial preparation will be carried out and thawing of the embryo and its transfer will be performed.
Similarly, each case will be individualized taking into account the situation and medical history of each patient.
About Iranian Surgery
Iranian surgery is an online medical tourism platform where you can find the best infertility specialists in Iran. The price of IVF treatment in Iran can vary according to each individual’s case and will be determined by an in-person assessment with the doctor.
For more information about the cost of IVF treatment in Iran and to schedule an appointment in advance, you can contact Iranian Surgery consultants via WhatsApp number 0098 901 929 0946. This service is completely free.